Most have involved obscuring of eye color change surgery the skin of the eyelids and periocular area. There were a couple of reports of hyperpigmentation of the neck, back, or fleeting region of the face. One report of vitiligo and one more of periocular depigmentation in a person of color were gotten by the WAES. The announced season of event went from 3 weeks to 1 year after inception of Xalatan treatment, and the patients included were generally ladies matured 47 to 80 years. Since the finish of 1999, there have been 13 reports recorded at the National Registry of Drug-Induced Ocular Side Effects (NRDIOSE) of periocular skin variety changes purportedly brought about by latanoprost (composed correspondence, Frederick T. Fraunfelder, MD, February 10, 2000).

The WAES and NRDIOSE case reports are spontaneous and nonsubstantiated and may not necessarily address substantial unfavorable impacts of a medicine. Curiously, a hunt of different clinical information bases from 1964 through January 2000 showed no report of hyperpigmentation of periocular skin related with the utilization of latanoprost eye drops. There has been just 1 report of hyperpigmentation of periocular skin from an effective eye drop; this elaborate a patient utilizing a β-blocker.9

Likewise with the underlying report of hyperpigmentation of the eyelashes, we suspect that expanded consciousness of periocular skin change as an unfavorable impact of latanoprost will uncover a surprisingly boundless predominance. It ought to be perceived, in any case, that the progressions in color of the iris, eyelashes, and periocular skin appear to be harmless and of minimal more than restorative results. Moreover, the skin changes appear to be reversible with ending utilization of the medicine. The travel time from the basal layer to the defined corneum is 4 to 5 weeks, and shedding of the cornified layer requires fourteen days more. In this manner, it requires no less than 7 weeks for skin pigmentation to vanish in the wake of ending utilization ofAn individual’s eye variety results from pigmentation of a design called the iris, which encompasses the little dark opening in the focal point of the eye (the understudy) and helps control how much light can enter the eye. The shade of the iris goes on a continuum from exceptionally light blue to dim brown. More often than not eye tone is classified as blue, green/hazel, or brown. Brown is the most regular eye tone around the world. Lighter eye tones, like blue and green, are found solely among individuals of European family.